Efficacy of Pentoxifylline

Study Objective

  • Currently, there is debate as to whether pentoxifylline has any efficacy in preventing the progression of PD (curvature, deformity, pain, length changes) in men who have newly discovered PD

  • The objective of the current study is to evaluate the efficacy of pentoxifylline on preventing or improving penile curvature, pain, length changes, or deformity when taken within 3 months of disease onset

  • To accomplish this objective, 40 men will be randomized into either pentoxifylline or placebo and followed until they are 6 months out from disease onset

Study Details

  • Men wishing to participate will be randomly assigned to either placebo (sugar pill) or pentoxifylline until the participant is 6 months out from disease onset

  • In-office measurements will be obtained at baseline, 6 weeks after starting treatment, and once the patient is 6 months out from disease onset

  • Study questionnaires will be obtained either in person or electronically at baseline, 6 weeks, once 6 months out from disease onset, and 1 year after study initiation

Who May Participate

  • A total of 40 men will be enrolled

  • Must have new onset PD (within 3 months of first noticing any aspect of PD: pain, curvature, nodularity, other deformity)

  • Ability to achieve an erection satisfactory for intercourse with or without PDE5 inhibitors (e.g. Viagra, Levitra, Cialis, Stendra)

  • No prior treatment of PD

Finances and Remuneration

  • Participants in the clinical study will have all study related costs paid for, including the cost of clinical evaluation, penile ultrasound, and treatment (placebo or pentoxifylline)

  • Transportation costs will also be reimbursed up to $500 per trip

  • Participants will also be given up to $600 for participation (if completing all visits and questionnaires)

How Do I Enroll

  • The study is currently seeking funding and will begin once sufficient funding has been secured

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Funding Required to Initiate Study

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Percentage of Study Funding Received

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